PLAG LAB

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PLAG 연구, 제조사

엔지켐 생명과학

천연물(녹용)유래 물질 EC-18(PLAG)을 이용한 항암제로 유발되는 호중구 및 혈소판 감소증...

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PLAG 특허

질환별 PLAG 특허

호중구 감조증, 구강점막염, 류마티스관절염, 면역조절제 및 항암제, 아토피, 천식, 혈액암 등...

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PLAG 언론보도

PLAG 최신소식

엔지켐 'EC-18', 산통부 '첨단기술' 인증 기술 특허 등 국가 공인…신약후보물질 개발에 탄력...

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PLAG 연구소

PLAG 연구, 임상결과

PLAG는 GEMCITABINE 유발 호중구감소증의 발생률을 감소시킬 것이다: 파일럿 사례 연구

in vivo Study (동물실험)
호중구감소증

Background: Chemotherapy-induced neutropenia (CIN) may compromise planned chemotherapy, resulting in severe infection, dose reduction or delayed treatment. Orally administered 1-pamitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) is a synthetic monoacetyldiglyceride, a product found in the antlers of sika deer.

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무작위 통제 시험에서 건강한 성인의 면역 기능에 대한 PLAG의 효과

Clinical Study (임상시험)
면역기능

We previously reported that 1-palmitoyl-2-linoleoyl-3- acetyl-rac-glycerol (PLAG) accelerates hematopoiesis and has an improving effect on animal disease models such as sepsis and asthma. The effects of PLAG supplementation on immune modulation were assessed in healthy men and women.

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햄스터와 마우스의 구강점막염에 대한 PLAG의 치료 효과

in vivo Study (동물실험)
구강점막염

Chemotherapy-induced mucositis can limit the effectiveness of cancer therapy and increase the risk of infections. However, no specific therapy for protection against mucositis is currently available.

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PLAG는 마우스에서 거핵세포/적혈구 전구세포 분화의 촉진을 통해 화학요법에 의해 유도된 혈소판감소증을 경감시킨다.

in vivo Study (동물실험)
혈소판감소증

Previously, PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol, acetylated diglyceride) was reported to have an effect on the proliferation of hematopoietic stem cells (HSCs) or to contribute to the prevention of chemotherapy-induced neutropenia.

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합성 MONOACETYLDIGLYCERIDE인 EC-18은 햄스터 모델에서 KIGB-5 담도암 세포의 혈행 전이를 억제한다.

in vivo Study (동물실험)
암전이

EC-18 (monoacetyldiacylglyceride) stimulates T cell production of IL-2, IL-4, IL-12, IFN-γ, and GM-CSF in vitro. To study the effects of these cytokines stimulated by EC-18 on cancer cells, we applied hamster biliary cancer model, a difficult cancer to treat.

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EC-18은 IL-4의 감소를 통해 TH2 면역을 조절한다.

in vivo Study (동물실험)
아토피 피부염

Controlling balance between T-helper type 1 (Th1) and T-helper type 2 (Th2) plays a pivotal role in maintaining the biological rhythm of Th1/Th2 and circumventing diseases caused by Th1/Th2 imbalance.

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PLAG는 IL-6/STAT3/MIP-2 활성에 의해 호중구 침윤을 감소시킴으로써 관절염에 걸린 관절을 개선한다.

in vivo Study (동물실험)
류마티스관절염

The pathogenesis of rheumatoid arthritis (RA) has been implicated neutrophil extracellular traps (NETs) formation which could generate autoantigen. Neutrophil contributes to initiate and maintain the inflammatory process in the joint.

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합성 MONOACETYLDIGLYCERIDE인 EC-18은 수산화 알루미늄, 오발부민 유도 천식 모델에서 천식 반응을 감소시킨다.

in vivo Study (동물실험)
천식

EC-18 is a synthetic monoacetyldiaglyceride that is a major constituent in antlers of Sika deer (Cervus nippon Temmenick). In this study, we evaluated the protective effects of EC-18 on Th2-type cytokines, eosinophil infiltration, and other factors in an aluminum hydroxide/ovalbumin (OVA)-induced murine asthma model.

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합성 MONOACETYLDIGLYCERIDE의 장관 투여는 복부 패혈증의 마우스 모델에서 생존율을 향상시킨다.

in vivo Study (동물실험)
패혈증

Background: A monoacetyldiglyceride (MADG) markedly improves survival in a murine model of abdominal sepsis. MADGs have been shown to stimulate hematopoiesis in vitro. We examined effects of MADG administration in setting of cecal ligation and puncture (CLP)

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PLAG는 CONCANAVALIN A를 처리한 마우스에서 간 손상을 감소시킨다.

in vivo Study (동물실험)
간염

Abstract 26 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG), a chemically synthesized 27 monoacetyldiaglyceride, is one of the constituents in Sika deer antlers and has been known 28 traditionally as having immunomodulatory effects.

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담배연기와 LIPOPOLYSACCHARIDE에 의해 유도된 설치류 폐 염증 모델에서 합성 MONOACETYLDIGLYCERIDE인 EC-18의 보호 효과

in vivo Study (동물실험)
만성폐쇄성폐질환

The antler of Sika deer (Cervus nippon Temminck) has been used a natural medicine in Korea, China and Japan, and a monoacetyldiaglyceride (1-palmitoyl-2-linoleoyl-3-acetylglycerol, PLAG) was found in the antler of Sika deer as a constituent for immunomodulation.

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조혈에 대한 MONOACETYLDIGLYCERIDE의 자극 효과

in vitro Study (세포실험)
조혈작용

In traditional Oriental medicine, extracts from the antler of the deer, Cervus nippon TEMMENICK (Cervidae), have been used to treat a variety of ailments for over thousands years. Traditionally, water extracts of deer antler were used as “tonics” for patients with anemia, anorexia, and fatigue.1—3) More recently, deer antler extract was observed to accelerate recovery from hematopoietic injuries induced by cancer chemotherapy and/or radiation therapy.

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급성방사선증후군에 대한 PLAG의 효과

급성방사선증후군

This letter responds to your request submitted on behalf of Enzychem Lifesciences Corporation for orphan-drug designation of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol for "treatment of acute radiation syndrome."

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PLAG 자문위원 소개

최신 소식

영상자료, 언론보도

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