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PLAG 피엘에이지의
40년의 연구개발의 결실 -
PLAG 작용기전 - 사이토카인,케모카인 분비 조절 /
면역세포 이동 조절 염증반응 조절 -
PLAG 피엘에이지의
질환별 연구, 임상결과 -
Background: Chemotherapy-induced neutropenia (CIN) may compromise planned chemotherapy, resulting in severe infection, dose reduction or delayed treatment. Orally administered 1-pamitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) is a synthetic monoacetyldiglyceride, a product found in the antlers of sika deer.
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We previously reported that 1-palmitoyl-2-linoleoyl-3- acetyl-rac-glycerol (PLAG) accelerates hematopoiesis and has an improving effect on animal disease models such as sepsis and asthma. The effects of PLAG supplementation on immune modulation were assessed in healthy men and women.
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Chemotherapy-induced mucositis can limit the effectiveness of cancer therapy and increase the risk of infections. However, no specific therapy for protection against mucositis is currently available.
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Previously, PLAG (1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol, acetylated diglyceride) was reported to have an effect on the proliferation of hematopoietic stem cells (HSCs) or to contribute to the prevention of chemotherapy-induced neutropenia.
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EC-18 (monoacetyldiacylglyceride) stimulates T cell production of IL-2, IL-4, IL-12, IFN-γ, and GM-CSF in vitro. To study the effects of these cytokines stimulated by EC-18 on cancer cells, we applied hamster biliary cancer model, a difficult cancer to treat.
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Controlling balance between T-helper type 1 (Th1) and T-helper type 2 (Th2) plays a pivotal role in maintaining the biological rhythm of Th1/Th2 and circumventing diseases caused by Th1/Th2 imbalance.
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The pathogenesis of rheumatoid arthritis (RA) has been implicated neutrophil extracellular traps (NETs) formation which could generate autoantigen. Neutrophil contributes to initiate and maintain the inflammatory process in the joint.
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EC-18 is a synthetic monoacetyldiaglyceride that is a major constituent in antlers of Sika deer (Cervus nippon Temmenick). In this study, we evaluated the protective effects of EC-18 on Th2-type cytokines, eosinophil infiltration, and other factors in an aluminum hydroxide/ovalbumin (OVA)-induced murine asthma model.
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Background: A monoacetyldiglyceride (MADG) markedly improves survival in a murine model of abdominal sepsis. MADGs have been shown to stimulate hematopoiesis in vitro. We examined effects of MADG administration in setting of cecal ligation and puncture (CLP)
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Abstract 26 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG), a chemically synthesized 27 monoacetyldiaglyceride, is one of the constituents in Sika deer antlers and has been known 28 traditionally as having immunomodulatory effects.
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The antler of Sika deer (Cervus nippon Temminck) has been used a natural medicine in Korea, China and Japan, and a monoacetyldiaglyceride (1-palmitoyl-2-linoleoyl-3-acetylglycerol, PLAG) was found in the antler of Sika deer as a constituent for immunomodulation.
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In traditional Oriental medicine, extracts from the antler of the deer, Cervus nippon TEMMENICK (Cervidae), have been used to treat a variety of ailments for over thousands years. Traditionally, water extracts of deer antler were used as “tonics” for patients with anemia, anorexia, and fatigue.1—3) More recently, deer antler extract was observed to accelerate recovery from hematopoietic injuries induced by cancer chemotherapy and/or radiation therapy.
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This letter responds to your request submitted on behalf of Enzychem Lifesciences Corporation for orphan-drug designation of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol for "treatment of acute radiation syndrome."
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